Carcinogenesis: Double whammy

Natural products: DNA double whammy.

Varitint-waddler: a double whammy for hearing.

T varitint-waddler (Va) mutant mouse must be the prettiest mouse I have ever seen. The mutation shows semidominant inheritance, and mice carrying one copy of the Va mutation are tricolored, as its name suggests, with variable patches of fur in white, pale gray, and the rich chestnut color agouti (1). It is also deaf and has the classic head-bobbing and circling behavior typical of mice with def...

Double whammy: a tale of two malignancies.

Sharma A, Yesudian PD. BMJ Case Rep 2017. doi:10.1136/bcr-2017-221148 Description A 61-year-old woman was referred to the dermatology clinic with multiple skin lesions on her scalp and central back. They were relatively asymptomatic but had increased in size over the previous few months. Her medical history was significant as she had a cerebellar medulloblastoma when she was 19 years old that w...

Comorbid depression and diabetes mellitus: a double whammy

Depression is commonly found as a comorbid condition in chronic medical illnesses in general, and diabetes mellitus in particular. Patients with diabetes are twice as likely to suffer from depression as compared to the general population. The relationship between depression and diabetes has been argued to be essentially bi-directional. Coexistence of diabetes and depression is associated with p...

Effective double whammy targets DNA synthesis in leukemia

384 INSIGHTS | The Journal of Experimental Medicine Inhibition of DNA synthesis is a keystone of cancer therapy. The purine and pyrimidine precursors of DNA are obtained either by the de novo pathway (DNP) or the nucleotide salvage pathway (NSP). The DNP generates nucleotides that are reduced to the corresponding deoxynucleotide by ribonucleotide reductase (RNR). Thymidine, a potent inhibitor o...